Astronauts during space missions, deep-sea researchers, high-altitude climbers, and workers exposed to radiation hazards, are highly prone to hastened process of aging and inflammaging, reflected by increase in NLR, Interleukin-6, gut dysbiosis and i

호중구 대 림프구 비율(Neutrophil to Lymphocyte ratio, NLR)은 우주 임무 중 우주 비행사의 건강과 노화 관련 질병, 염증, 수명 및 암 예후의 중요한 생체표지자다. 아우레오바시디움 풀루란스(Aureobasidium pullulans) AFO-202 균주 생성 니치 브라이트(Nichi BRITE)와 N-163 균주 생성 뉴 리픽스(Neu REFIX)의 경구 섭취(전임상 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.clicom.2021.11.001&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=pre-clinical&index=1&md5=6cb648e6d72464a7f56a4a9398db3344) 및 임상 연구 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.14283%2Fjarlife.2023.11&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=clinical+studies&index=2&md5=555dc6a44aba572c5e4f7521309d5545)에서) NLR을 안전하고 유익하게 변형해 우주 비행 중 우주 비행사의 건강을 유지 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3389%2Ffimmu.2025.1538147&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=maintain+astronauts+health+during+space+flight&index=3&md5=e572d0847091bbba984651f1658c4f92)하는 데 도움이 되고 Me-Byo’ (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3389%2Ffpubh.2023.1142281&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=Me-Byo%26%238217%3B&index=4&md5=f5699259a5cb474df4e57e4b163a3125) 현상에 의한 건강 수명과 수명 사이의 격차를 해소((프론티어스 인 이뮤놀로지(Frontiers in Immunology) (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3389%2Ffpubh.2024.1495056&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=Frontiers+in+Immunology&index=5&md5=07b63c30742f8e202267f325f93d3670)에서 발표)하는 한편 뉴 리픽스 독립형은 강화된 디스트로핀 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs41598-025-92258-4&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=enhanced+dystrophin&index=6&md5=c3db900ef1a3ba42c36749eea8f423ef)을 생성하고, 우주 임무 중 근육 손실을 방지하는 데 도움이 될 수도 있는 잠재력을 가지고 있다고 간주된다.

우주 여행 중 우주 비행사는 전리 방사선, 일주기 리듬 붕괴 및 미세 중력에 노출돼 스트레스, 염증 및 면역 기능 장애를 유발하며, 이는 NLR의 증가로 반영된다. 저자들에 따르면 NLR을 유익하게 조절하는 것으로 보고된 식품 보조제를 사용하는 안전한 중재는 없었다. 저자들은 이렇게 덧붙였다: 니치 브라이트가 면역 효과 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3892%2For.2021.8225&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=immune+enhancement&index=7&md5=8a92d05b441c59398d4760e243449e1e) 및 항암 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fascopubs.org%2Fdoi%2F10.1200%2FJCO.2024.42.23_suppl.96&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=anti-cancer&index=8&md5=a1b8773dc0f93b8263afa42d8b62317a) 효과를 보고하고 뉴 리픽스는 강화된 중력 감지 디스트로핀과 별도로 면역 조절 및 항섬유화 효과 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.jceh.2022.06.008&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=anti-fibrotic+effects&index=9&md5=71094e85dcc7394353276b9e14f79540)를 보고하고(전임상 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs41598-025-92258-4&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=pre-clinical&index=10&md5=dc8afbf88f484e448f1945f99ad731d0) 및 임상 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.ibneur.2023.06.007&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=clinical&index=11&md5=530be5c5379b1331bb8a60936b8e5882) 연구에서), 함께 섭취하면 건강과 수명의 지표인 부티레이트를 강화하며 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fgeomednews.com%2FArticles%2F2023%2F3_2023%2F73-78.pdf&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=enhances+butyrate&index=12&md5=62867fd7adc6d14936e65f69f3d4ecd4)(유익한 장내 마이크로바이옴 조절 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1136%2Fbmjgast-2022-000985&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=gut+microbiome+modulation&index=13&md5=4dfc597216c04917d7ea20a0b47c537d)을 통해) 시뮬레이션된 미세중력 및 취약 인구, 특별히 면역 훼손 및 자가 면역 질환에 대한 추가 연구는 가치가 있다. 이러한 잠재력은 건강 수명과 수명 사이의 격차를 해소할 수 있다. 뉴 리픽스는 뒤셴 근이영양증(Duchenne Muscular Dystrophy, DMD) 치료를 위해 미국 FDA로부터 ODD 및 RPD (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.accessdata.fda.gov%2Fscripts%2Fopdlisting%2Foopd%2FdetailedIndex.cfm%3Fcfgridkey%3D1019624&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=ODD+and+RPD&index=14&md5=464fb9e2b08917709597ed728c4279f6)를 승인받았다.

우주 비행 중 노화 및 염증의 과정과 NLR과 디스트로핀 수치에 의해 반영된 노년기와 유사한 근육 질량 감소를 급속하게 하고, 식품 보조제로 일본에서 제조된 이런 독특한 엑소 다당류 베타 글루칸 (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.nichiglucan.com%2Fpublications.html&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=unique+exo-polysaccharide+beta+glucans&index=15&md5=e8972e1ff3ad043378a40b5a31d94e6b)에 의해 유익하게 수정되는 것은 우주 여행과 노화 및 장수 관련 건강 지수에 도움이 될 수 있는 새로운 연구 영역을 연다. 연구는 또한 심해 연구자, 고산 등반가, 극지 탐험대 및 방사능 위험에 취약한 근로자와 같은 혹독한 환경 조건에서 일하는 개인의 건강과 회복력에 도움이 될 수도 있다.

*B-1,3-1,6 글루칸은 일본 MHLW에 등록된 식품 첨가물 (https://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww.mhlw.go.jp%2Fweb%2Ft_doc%3FdataId%3D78332210%26datatype%3D0%26pageNo%3D1&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=listed+food+additive+in+MHLW%2C+Japan&index=16&md5=d4b850d12a2ad97ffa4bcb0097bda08d) 이다. 어떤 질병에 대한 약물이나 치료법이 아니다. 연구 결과는 의학적 조언으로 해석되어서는 안된다. GRAS가 아닌 EFSA 인증.

사진/멀티미디어 자료 : https://www.businesswire.com/news/home/20250316966059/en

Neutrophil to Lymphocyte ratio (NLR) is a critical biomarker of health of astronauts during space mission, and that of aging related illnesses, inflammaging, longevity and cancer prognosis. Oral consumption of AFO-202 strain of Aureobasidium pullulans produced Nichi BRITE and N-163 strain produced Neu REFIX together in pre-clinical (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.clicom.2021.11.001&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=pre-clinical&index=1&md5=6cb648e6d72464a7f56a4a9398db3344) and clinical studies (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.14283%2Fjarlife.2023.11&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=clinical+studies&index=2&md5=555dc6a44aba572c5e4f7521309d5545) having safely and beneficially modified NLR, are considered holding potential to help maintain astronauts health during space flight (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3389%2Ffimmu.2025.1538147&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=maintain+astronauts+health+during+space+flight&index=3&md5=e572d0847091bbba984651f1658c4f92) and also to bridge the gap between health span and life span by ‘Me-Byo (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3389%2Ffpubh.2023.1142281&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=Me-Byo%26%238217%3B&index=4&md5=f5699259a5cb474df4e57e4b163a3125)’ phenomenon as published in Frontiers in Immunology (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3389%2Ffpubh.2024.1495056&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=Frontiers+in+Immunology&index=5&md5=07b63c30742f8e202267f325f93d3670) while Neu REFIX standalone yielding enhanced dystrophin (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs41598-025-92258-4&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=enhanced+dystrophin&index=6&md5=c3db900ef1a3ba42c36749eea8f423ef), an additional benefit that might help prevent muscle loss during space missions.

Astronauts during space travel are exposed to ionizing radiation, circadian rhythm disruption and microgravity leading to stress, inflammation and immune dysfunction which reflects as an increase in NLR. There has been no safe intervention using a food supplement reported yet beneficially modifying NLR, according to the authors. They added that Nichi BRITE reporting immune enhancement (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.3892%2For.2021.8225&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=immune+enhancement&index=7&md5=8a92d05b441c59398d4760e243449e1e) and anti-cancer (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fascopubs.org%2Fdoi%2F10.1200%2FJCO.2024.42.23_suppl.96&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=anti-cancer&index=8&md5=a1b8773dc0f93b8263afa42d8b62317a) effects, Neu REFIX for its immune modulation and anti-fibrotic effects apart from enhanced gravisensing dystrophin in pre-clinical (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs41598-025-92258-4&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=pre-clinical&index=10&md5=dc8afbf88f484e448f1945f99ad731d0) and clinical (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.ibneur.2023.06.007&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=clinical&index=11&md5=530be5c5379b1331bb8a60936b8e5882) studies; when consumed together efficiently enhances butyrate (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fgeomednews.com%2FArticles%2F2023%2F3_2023%2F73-78.pdf&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=enhances+butyrate&index=12&md5=62867fd7adc6d14936e65f69f3d4ecd4), an indicator of health and longevity through beneficial gut microbiome modulation (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fdoi.org%2F10.1136%2Fbmjgast-2022-000985&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=gut+microbiome+modulation&index=13&md5=4dfc597216c04917d7ea20a0b47c537d) are worth further research in simulated microgravity and for vulnerable populations, specially immunocompromised and in auto-immune diseases. These potentials may bridge the gap between health span and lifespan. Neu REFIX has been granted ODD and RPD (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.accessdata.fda.gov%2Fscripts%2Fopdlisting%2Foopd%2FdetailedIndex.cfm%3Fcfgridkey%3D1019624&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=ODD+and+RPD&index=14&md5=464fb9e2b08917709597ed728c4279f6) by US FDA for treatment of Duchenne Muscular Dystrophy (DMD).

Hastening process of aging & inflammaging during space flight and muscle mass reduction similar to old age reflected by NLR and dystrophin levels, being beneficially modified by these unique exo-polysaccharide beta glucans (https://cts.businesswire.com/ct/CT?id=smartlink&url=https%3A%2F%2Fwww.nichiglucan.com%2Fpublications.html&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=unique+exo-polysaccharide+beta+glucans&index=15&md5=e8972e1ff3ad043378a40b5a31d94e6b) manufactured in Japan as food supplements open a new area of research which could help space travel and also aging & longevity related health indices. Research could also be of help in the health and resilience of individuals working in harsh environmental conditions such as deep-sea researchers, high-altitude climbers, polar expeditions and workers prone to radiation hazards.

*B-1,3-1,6 glucan is a listed food additive in MHLW, Japan (https://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww.mhlw.go.jp%2Fweb%2Ft_doc%3FdataId%3D78332210%26datatype%3D0%26pageNo%3D1&esheet=54224554&newsitemid=20250316966059&lan=en-US&anchor=listed+food+additive+in+MHLW%2C+Japan&index=16&md5=d4b850d12a2ad97ffa4bcb0097bda08d); Not a drug or remedy to any illness. Research findings should not be construed as medical advice. Not GRAS, EFSA certified.

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언론연락처: GN Corporation Co Ltd Samuel JK Abraham

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